Dr. Andrew J. Cole

Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ. Silent Hippocampal Seizures Identified by Foramen Ovale Electrodes in Alzheimer’s Disease. Nat Med. 2017 May 1. doi: 10.1038/nm.4330. [Epub ahead of print] PMID:28459436. PDF

Vaitkevicius H, Bobb W, Rosenthal ES, Rosand J, Husain AM, Reddy K, Rogawski MA, Cole AJ. First-in-Man Allopregnanolone Use in Super-Refractory Status Epilepticus. Annals Clinical and Translational Neurology. 2017 April 25 [Epub ahead of print]. PDF

Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King-Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017 Apr 7. doi: 10.1111/epi.13739. [Epub ahead of print] PMID:28387951. PDF

Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE Jr, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy.Epilepsia. 2017 Apr 11. doi: 10.1111/epi.13740. [Epub ahead of print] PMID:28398014. PDF

McKenzie ED, Lim AS, Leung EC, Cole AJ, Lam AD, Eloyan A, Nirola DK, Tshering L, Thibert R, Garcia RZ, Bui E, Deki S, Lee L, Clark SJ, Cohen JM, Mantia J, Brizzi KT, Sorets TR, Wahlster S, Borzello M, Stopczynski A, Cash SS, Mateen FJ. Validation of a smartphone-based EEG among people with epilepsy: A prospective study.Sci Rep. 2017 Apr 3;7:45567. doi: 10.1038/srep45567.PMID:28367974. PDF

McKenzie ED, Nirola DK, Deki S, Tshering L, Patenaude B, Clark SJ, Cash SS, Thibert R, Zepeda R, Leung EC, Lam AD, Lim AS, Mantia J, Cohen J, Cole AJ, Mateen FJ. Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan. Epilepsy Behav. 2016 Jun;59:122-7. doi: 10.1016/j.yebeh.2016.03.035. PMID: 27131914. PDF

McGrath ER, Batra A, Lam AD, Rizzo JF 3rd, Cole AJ. Clinical Reasoning: A 64-year-old man with visual distortions. Neurology. 2016 Nov 22;87(21):e252-e256. PMID: 27872229. PDF

van Vliet EA, Dedeurwaerdere S, Cole AJ, Friedman A, Koepp MJ, Potschka H, Immonen R, Pitkänen A, Federico P. WONOEP appraisal: Imaging biomarkers in epilepsy. Epilepsia. 2016 Nov 24. doi: 10.1111/epi.13621. [Epub ahead of print] Review. PMID: 27883181. PDF

Moura LM, Westover MB, Kwasnik D, Cole AJ, Hsu J. Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly. Clin Epidemiol. 2016 Dec 30;9:9-18. doi: 10.2147/CLEP.S121023. PMID: 28115873. PDF

Moura LM, Price M, Cole AJ, Hoch DB, Hsu J. Accuracy of claims-based algorithms for epilepsy research: Revealing the unseen performance of claims-based studies. Epilepsia. 2017 Feb 15. doi: 10.1111/epi.13691. [Epub ahead of print] PMID: 28199007. PDF

Moura LM, Carneiro TS, Cole AJ, Hsu J, Vickrey BG, Hoch DB. Association between addressing antiseizure drug side effects and patient-reported medication adherence in epilepsy. Patient Prefer Adherence. 2016 Oct 31;10:2197-2207. PMID: 27826186. PDF

Moura LM, Schwamm E, Moura Junior V, Seitz MP, Hsu J, Cole AJ, Schwamm LH. Feasibility of the collection of patient-reported outcomes in an ambulatory neurology clinic. Neurology. 2016 Nov 4. pii: 10.1212/WNL.0000000000003409. PMID: 27815405. PDF

Moura LM, Eskandar EN, Hassan M, Salinas J, Cole AJ, Hoch DB, Cash SS, Hsu J. Anterior temporal lobectomy for older adults with mesial temporal sclerosis.  Epilepsy Res. 2016 Nov;127:358-365. doi: 10.1016/j.eplepsyres.2016.09.021. PMID: 27760412. PDF

Ng MC, Kilbride R, Simon M, Eskandar E, Cole AJ. Hippocampography Guides Consistent Mesial Resections in Neocortical Temporal Lobe Epilepsy. Epilepsy Res Treat. 2016;2016:3581358. PMID: 27703809. PDF

Cole AJ. Status Epilepticus and Brain Atrophy: Shrinkage Is a Growing Problem. JAMA Neurol. 2016 Oct 1;73(10):1182-1183. doi: 10.1001/jamaneurol.2016.2639. PMID: 27532774. PDF

Lam AD, Zepeda R, Cole AJ, Cash SS. Widespread changes in network activity allow non-invasive detection of mesial temporal lobe seizures. Brain. 2016 Oct;139(Pt 10):2679-2693. PMID: 27474219. PDF

Takaya S, Liu H, Greve DN, Tanaka N, Leveroni C, Cole AJ, Stufflebeam SM. Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy. Hum Brain Mapp. 2016 Jul 25. doi: 10.1002/hbm.23319. PMID: 27452151. PDF

Moura LM, Carneiro TS, Thorn EL, Seitz MP, Hsu J, Cole AJ, Vickrey BG, Hoch DB.Patient perceptions of physician-documented quality care in epilepsy. Epilepsy Behav. 2016 Sep;62:90-6. doi: 10.1016/j.yebeh.2016.06.024. PMID: 27450312. PDF

Hotan GC, Struck AF, Bianchi MT, Eskandar EN, Cole AJ, Westover MB. Decision analysis of intracranial monitoring in non-lesional epilepsy. Seizure. 2016 Aug;40:59-70. doi: 10.1016/j.seizure.2016.06.010. PMID: 27348062. PDF

Muniz CF, Shenoy AV, OʼConnor KL, Bechek SC, Boyle EJ, Guanci MM, Tehan TM, Zafar SF, Cole AJ, Patel AB, Westover MB, Rosenthal ES. Clinical Development and Implementation of an Institutional Guideline for Prospective EEG Monitoring and Reporting of Delayed Cerebral Ischemia. J Clin Neurophysiol. 2016 Jun;33(3):217-26. doi: 10.1097/WNP.0000000000000281. PMID: 27258445. PDF

Struck AF, Westover MB, Hall LT, Deck GM, Cole AJ, Rosenthal ES. Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG. Neurocrit Care. 2016 Jun;24(3):324-31. doi: 10.1007/s12028-016-0245-y. PMID: 27169855. PDF

Douw L, DeSalvo MN, Tanaka N, Cole AJ, Liu H, Reinsberger C, Stufflebeam SM. Ann Clin Transl Neurol. Dissociated multimodal hubs and seizures in temporal lobe epilepsy. 2015 Apr;2(4):338-52. doi: 10.1002/acn3.173. Epub 2015 Feb 25. PMID: 25909080. PDF

Struck AF, Cole AJ, Cash SS, Westover MB. The number of seizures needed in the EMU.Epilepsia. 2015 Jul 27. doi: 10.1111/epi.13090. [Epub ahead of print] PMID: 26222350. PDF

King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia. 2015 Jun;56(6):959-67. doi: 10.1111/epi.13010. Epub 2015 May 19. PMID: 25988840. PDF

Akama-Garren EH, Bianchi MT, Leveroni C, Cole AJ, Cash SS, Westover MB. Weighing the value of memory loss in the surgical evaluation of left temporal lobe epilepsy: A decision analysis. Epilepsia. 2014 Sep 19. doi: 10.1111/epi.12790. PMID:25244498. PDF

Cole AJ, So NK, Tandon N, Slater JD, Smith MC.  Judgment is not ignorance. Neurology. 2014 Aug 26;83(9):847. doi: 10.1212/WNL.0000000000000742. PMID:25156349. PDF

So NK, Cole AJ, Tandon N, Slater JD, Smith MC. Neurostimulation for the treatment of epilepsy: The skeptical view. Neurology. 2014 Aug 26;83(9):847-9. doi: 10.1212/WNL.0000000000000740. PMID:25156350. PDF

Westover MB, Shafi MM, Bianchi MT, Moura LM, O’Rourke D, Rosenthal ES, Chu CJ, Donovan S, Hoch DB, Kilbride RD, Cole AJ, Cash SS. The probability of seizures during EEG monitoring in critically ill adults. Clin Neurophysiol. 2014 Jul 11. pii: S1388-2457(14)00362-9. doi: 10.1016/j.clinph.2014.05.037. PMID:25082090. PDF

Moura LM, Shafi MM, Ng M, Pati S, Cash SS, Cole AJ, Hoch DB, Rosenthal ES, Westover MB. Spectrogram screening of adult EEGs is sensitive and efficient. Neurology. 2014 Jul 1;83(1):56-64. doi: 10.1212/WNL.0000000000000537. Epub 2014 May 23. PMID:24857926. PDF

Karakis I, Cole AJ, Montouris GD, San Luciano M, Meador KJ, Piperidou C.  Caregiver burden in epilepsy: determinants and impact. Epilepsy Res Treat. 2014;2014:808421. doi: 10.1155/2014/808421. Epub 2014 Apr 8. PMID:24808956. PDF

Pati S, Cole AJ. How focal is generalized epilepsy: a distinction with a difference? Epilepsy Behav. 2014 May;34:127-8. doi: 10.1016/j.yebeh.2014.03.007. Epub 2014 Apr 6. PMID:24713435. PDF

Sheth SA, Aronson JP, Shafi MM, Phillips HW, Velez-Ruiz N, Walcott BP, Kwon CS, Mian MK, Dykstra AR, Cole AJ, Eskandar EN.Utility of foramen ovale electrodes in mesial temporal lobe epilepsy. Epilepsia. 2014 May;55(5):713-24. doi: 10.1111/epi.12571. Epub 2014 Mar 7. PMID:24605889. PDF

Heck CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O’Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014 Mar;55(3):432-41. doi: 10.1111/epi.12534. Epub 2014 Feb 22. PMID:24621228. PDF

Karakis I, Montouris GD, Piperidou C, Luciano MS, Meador KJ, Cole AJ. The effect of epilepsy surgery on caregiver quality of life. Epilepsy Res. 2013 Nov;107(1-2):181-9. doi: 10.1016/j.eplepsyres.2013.08.006. Epub 2013 Sep 2. PMID: 24054427 PDF

Karakis I, Pathmanathan JS, Chang R, Cook EF, Cash SS, Cole AJ. Prognostic value of EEG asymmetries for development of drug-resistance in drug-naïve patients with genetic generalized epilepsies. Clin Neurophysiol. 2013 Oct 1. pii: S1388-2457(13)01020-1. doi: 10.1016/j.clinph.2013.07.028. PMID:24095154 PDF

Karakis I, Montouris GD, Piperidou C, Luciano MS, Meador KJ, Cole AJ. Patient and caregiver quality of life in psychogenic non-epileptic seizures compared to epileptic seizures. Seizure. 2014 Jan;23(1):47-54. doi: 10.1016/j.seizure.2013.09.011. Epub 2013 Sep 25. PMID: 24140136 PDF

Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley-Whyte ET, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multi-year incubation in human rabies. Ann Neurol. 2013 Aug 29. doi: 10.1002/ana.24016. PMID: 24038455 PDF

Reddy K, Reife R, Cole AJ .SGE-102: a novel therapy for refractory status epilepticus. Epilepsia. 2013 Sep;54 Suppl 6:81-3. doi: 10.1111/epi.12286. Review. PMID: 24001082 PDF

Hernandez-Lain A, Hedley-Whyte ET, Hariri LP, Molyneaux B, Nagle KJ, Cole AJ, Kilbride R. Pathology of bilateral pulvinar degeneration following long duration status epilepticus.Seizure. 2013 Dec;22(10):901-4. doi: 10.1016/j.seizure.2013.07.012. Epub 2013 Aug 17. PMID: 23962521 PDF

Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. Epilepsy biomarkers.Epilepsia. 2013 Aug;54 Suppl 4:61-9. doi: 10.1111/epi.12299. Review. PMID: 23909854 PDF

French JA, White HS, Klitgaard H, Holmes GL, Privitera MD, Cole AJ, Quay E, Wiebe S, Schmidt D, Porter RJ, Arzimanoglou A, Trinka E, Perucca E. Development of new treatment approaches for epilepsy: unmet needs and opportunities.Epilepsia. 2013 Aug;54 Suppl 4:3-12. doi: 10.1111/epi.12294. Review. PMID: 23909849 PDF

San-Juan D, Mayorga AP, Calcáneo Jde D, González-Aragón MF, Alonso-Vanegas M, Rico CD, Staba RJ, Anschel DJ, Cole AJ. Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis. Seizure. 2013 Nov;22(9):735-42. doi: 10.1016/j.seizure.2013.05.013. Epub 2013 Jun 18. PMID: 23787169 PDF

Cole AJ, Eskandar E, Mela T, Noebels JL, Gonzalez RG, McGuone D. Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness. N Engl J Med. 2013 Jun 13;368(24):2304-12. doi: 10.1056/NEJMcpc1215969. PMID: 23758236  PDF

Westover MB, Bianchi MT, Shafi M, Hoch DB, Cole AJ, Chiappa K, Cash SS. Inferring seizure frequency from brief EEG recordings. J Clin Neurophysiol. 2013 Apr;30(2):174-7. doi: 10.1097/WNP.0b013e3182767c35. PMID: 23545768 PDF

Shafi MM, Westover MB, Cole AJ, Kilbride RD, Hoch DB, Cash SS. Absence of early epileptiform abnormalities predicts lack of seizures on continuous EEG.Neurology. 2012 Oct 23;79(17):1796-801. doi: 10.1212/WNL.0b013e3182703fbc. Epub 2012 Oct 10. PMID: 23054233 PDF

Chang RS, Cole AJ. Lamotrigine-Induced Lupus-Like Syndrome: A Case Report and Literature Review. Am J Ther. 2012 Sep 24. PMID: 23011169 PDF

Karakis I, Chiappa KH, San Luciano M, Sassower KC, Stakes JW, Cole AJ The utility of routine EEG in the diagnosis of sleep disordered breathing. J Clin Neurophysiol. 2012 Aug;29(4):333-8. doi: 10.1097/WNP.0b013e31826244ae. PMID: 22854767

Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J Jr, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia. 2012 Nov;53(11):1860-7. doi: 10.1111/j.1528-1167.2012.03541.x. Epub 2012 Jun 18. Review. PMID: 22708847 PDF

Simon MV, Cole AJ, Chang EC, Buchbinder BR, Stufflebeam SM, Nozari A, Stemmer-Rachamimov AO, Eskandar EN. An intraoperative multimodal neurophysiologic approach to successful resection of precentral gyrus epileptogenic lesions. Epilepsia. 2012 Apr;53(4):e75-9. doi: 10.1111/j.1528-1167.2011.03400.x. Epub 2012 Feb 6. PMID: 22309192 PDF

Ritaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J, Viventi J, Williams J, Schalk G. Proceedings of the Second International Workshop on Advances in Electrocorticography. Epilepsy Behav. 2011 Dec;22(4):641-50. doi: 10.1016/j.yebeh.2011.09.028. Epub 2011 Oct 28. Review. PMID: 22036287 PDF

Oster JM, Igbokwe E, Cosgrove GR, Cole AJ. Identifying subtle cortical gyral abnormalities as a predictor of focal cortical dysplasia and a cure for epilepsy.Arch Neurol. 2012 Feb;69(2):257-61. doi: 10.1001/archneurol.2011.1002. Epub 2011 Oct 10. PMID: 21987396 PDF

Engel J Jr, McDermott MP, Wiebe S, Langfitt JT, Stern JM, Dewar S, Sperling MR, Gardiner I, Erba G, Fried I, Jacobs M, Vinters HV, Mintzer S, Kieburtz K;Early Randomized Surgical Epilepsy Trial (ERSET) Study Group. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA. 2012 Mar 7;307(9):922-30 PDF

Morrell MJ; RNS System in Epilepsy Study Group. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011 Sep 27;77(13):1295-304. Epub 2011 Sep 14. PDF

Westover MB, Cormier J, Bianchi MT, Shafi M, Kilbride R, Cole AJ, Cash SS. Revising the “Rule of Three” for inferring seizure freedom. Epilepsia. 2012 Feb;53(2):368-76. Epub 2011 Dec 22. PDF

Karakis I, Velez-Ruiz N, Pathmanathan JS, Sheth SA, Eskandar EN, Cole AJ. Foramen ovale electrodes in the evaluation of epilepsy surgery: Conventional and unconventional uses. Epilepsy Behav. 2011 Jul 20 [Epub ahead of print] PMID:21782522. PDF

Dibbens LM, Karakis I, Bayly MA, Costello DJ, Cole AJ, Berkovic SF. Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy. Arch Neurol. 2011 Jun;68(6):812-3. PMID: 21670406 PDF

San-Juan D, Mayorga AP, Anschel DJ, Avellán AM, González-Aragón MF, Cole AJ. The double generalization phenomenon in juvenile absence epilepsy. Epilepsy Behav. 2011 Jul;21(3):318-20. Epub 2011 May 14. PMID: 21571594. PDF

Karakis I, Cole AJ, Hoch DB, Sharma N. Extrapyramidal epilepsy. Epileptic Disord. 2011 Jun;13(2):181-4. PMID: 21561840, PDF

Sims KB, Cole AJ, Sherman JC, Caruso PA, Snuderl M. Case records of the Massachusetts General Hospital. Case 8-2011. A 32-year-old woman with seizures and cognitive decline. N Engl J Med. 2011 Mar 17;364(11):1062-74. PMID: 21410375. PDF

Cole AJ. Raymond Adams: A Life of Mind and Muscle. (Book review). Epilepsy & Behavior 19 (2010) 537. PDF

Reinsberger C, Tanaka N, Cole AJ, Lee JW, Dworetzky BA, Bromfield EB, Hamiwka L, Bourgeois BF, Golby AJ, Madsen JR, Stufflebeam SM. Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy. Neuroimage. 2010 Oct 1;52(4):1238-42. PMID: 20472073. PDF

Fiskerstrand T, H’mida-Ben Brahim D, Johansson S, M’zahem A, Haukanes BI, Drouot N, Zimmermann J, Cole AJ, Vedeler C, Bredrup C, Assoum M, Tazir M, Klockgether T, Hamri A, Steen VM, Boman H, Bindoff LA, Koenig M, Knappskog PM. Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. Am J Hum Genet. 2010 Sep 10;87(3):410-7.PMID: 20797687 [PubMed – indexed for MEDLINE]. PDF

Miller JW, Cole AJ. Is it necessary to define the ictal onset zone with EEG prior to performing epilepsy surgery? Epilepsy Behav. 2010 Sep 29. [Epub ahead of print]PMID: 20888304 PDF

San-Juan D, Chiappa KH, Cole AJ. Propofol and the electroencephalogram. Clin Neurophysiol. 2010 Jan 11. PMID: 20071229 [PubMed – as supplied by publisher]. PDF

Zheng Y, Moussally J, Cash SS, Karnam HB, Cole AJ. Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: Behavioral, physiological and histological studies. Neuropharmacology. 2009 Dec 21. PMID: 20026136 [PubMed – as supplied by publisher]. PDF

Orta DS, Chiappa KH, Quiroz AZ, Costello DJ, Cole AJ. Prognostic implications of periodic epileptiform discharges. Arch Neurol. 2009 Aug;66(8):985-91. PMID: 19667220 [PubMed – indexed for MEDLINE]. PDF

Tanaka N, Cole AJ, von Pechmann D, Wakeman DG, Hämäläinen MS, Liu H, Madsen JR, Bourgeois BF, Stufflebeam SM. Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. Epilepsy Res. 2009 Aug;85(2-3):279-86. Epub 2009 Apr 24. PMID: 19394198 [PubMed – indexed for MEDLINE]. PDF

Löscher W, Cole AJ, McLean MJ. Commentary: physical approaches for the treatment of epilepsy: electrical and magnetic stimulation and cooling. Neurotherapeutics. 2009 Apr;6(2):258-62. Review. PMID: 19332318 [PubMed – indexed for MEDLINE]. PDF

San-Juan OD, Chiappa KH, Costello DJ, Cole AJ. Periodic epileptiform discharges in hypoxic encephalopathy: BiPLEDs and GPEDs as a poor prognosis for survival. Seizure. 2009 Jun;18(5):365-8. Epub 2009 Feb 4. PMID: 19196524 [PubMed – indexed for MEDLINE]. PDF

Cole AJ, Wiebe S. Debate: Should antiepileptic drugs be stopped after successful epilepsy surgery Epilepsia. 2008 Dec;49 Suppl 9:29-34. PMID: 19087115 [PubMed – indexed for MEDLINE]. PDF

Costello DJ, Shields DC, Cash SS, Eskandar EN, Cosgrove GR, Cole AJ. Consideration of epilepsy surgery in adults should be independent of age. Clin Neurol Neurosurg. 2009 Apr;111(3):240-5. Epub 2008 Nov 22. PMID: 19028008 [PubMed – indexed for MEDLINE]. PDF

Costello DJ, Kilbride RD, Cole AJ. Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults-Infectious or not? J Neurol Sci. 2009 Feb 15;277(1-2):26-31. Epub 2008 Nov 17. PMID: 19013586 [PubMed – indexed for MEDLINE]. PDF

Costello DJ, Cole AJ. Treatment of acute seizures and status epilepticus. J Intensive Care Med. 2007 Nov Dec;22(6):319-47. Review. PMID: 18048876 [PubMed – indexed for MEDLINE]. PDF

Leeman BA, Cole AJ. Advancements in the Treatment of Epilepsy. Annu Rev Med. 2007 Sep 20; [Epub ahead of print] PMID: 17883367 [PubMed – as supplied by publisher]. PDF

Cole AJ. Hippocampal Sclerosis: An inflammatory hypothesis. Neurology 2007 Sept 18;69:1204-1205. PDF

Cole AJ, Henson JW, Roehrl MH, Frosch MP. Case records of the Massachusetts General Hospital. Case 24-2007. A 20-year-old pregnant woman with altered mental status. N Engl J Med. 2007 Aug 9;357(6):589-600. No abstract available. PMID: 17687135 [PubMed – indexed for MEDLINE]. PDF

Besio WG, Koka K, Cole AJ. Effects of Noninvasive Transcutaneous Electrical Stimulation via Concentric Ring Electrodes on Pilocarpine-induced Status Epilepticus in Rats. Epilepsia. 2007 Jul 25; PMID: 17651415. PDF

Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Sander T, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC.Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice. Am J Hum Genet. 2007 Apr;80(4):792-9. Epub 2007 Feb 12.
PMID: 17357084. PDF

Cole AJ. New screening tool for identifying major depression in patients with epilepsy. Nat Clin Pract Neurol. 2006 Dec;2(12):656-7. No abstract available. PMID: 17117168. PDF

Costello DJ, Simon MV, Eskandar EN, Frosch MP, Henninger HL, Chiappa KH, Cole AJ. Efficacy of surgical treatment of de novo, adult-onset, cryptogenic, refractory focal status epilepticus.
Arch Neurol. 2006 Jun;63(6):895-901. PMID: 16769873. PDF

Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res. 2006 Apr;69(1):80-86. Epub 2006 Mar 3. PMID: 16516443. PDF

Koh S, Santos TC, Cole AJ. Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain. Exp Neurol. 2005 Aug;194(2):457-66. PMID: 16022871. PDF

Brisman JL, Cosgrove GR, Thornton AF, Beer T, Bradley-Moore M, Shay CT, Hedley-Whyte ET, Cole AJ. Hyperacute neuropathological findings after proton beam radiosurgery of the rat hippocampus. Neurosurgery. 2005 Jun;56(6):1330-7; discussion 1337-8. PMID: 15918950. PDF

Rabinov JD, Brisman JL, Cole AJ, Lee PL, Bussiere MR, Chapman PH, Loeffler JS, Cosgrove GR, Chaves T, Gonzalez RG. MRI Changes in the Rat Hippocampus following Proton Radiosurgery. Stereotact Funct Neurosurg. 2004 Oct 19;82(4):156-164. PMID: 15499227 [PubMed – as supplied by publisher]. PDF

Cole AJ. Status epilepticus and periictal imaging. Epilepsia. 2004;45 Suppl 4:72-7. PMID: 15281962. PDF

Doherty CP, Cole AJ, Grant PE, Fischman A, Dooling E, Hoch DB, White TH, Cosgrove GR. Multimodal longitudinal imaging of focal status epilepticus. Can J Neurol Sci. 2004 May;31(2):276-81. PMID: 15198460 [PubMed – indexed for MEDLINE]. PDF

Oster J, Doherty C, Grant PE, Simon M, Cole AJ. Diffusion-weighted imaging abnormalities in the splenium after seizures. Epilepsia. 2003 Jun;44(6):852-4. PMID: 12790901. PDF

Brisman JL, Cole AJ, Cosgrove GR, Thornton AF, Rabinov J, Bussiere M, Bradley-Moore M, Hedley-Whyte T, Chapman PH. Radiosurgery of the rat hippocampus: magnetic resonance imaging, neurophysiological, histological, and behavioral studies. Neurosurgery. 2003 Oct;53(4):951-61. PMID: 14519227 [PubMed – indexed for MEDLINE]. PDF

Cole AJ. Evaluation and treatment of epilepsy in multiply handicapped individuals. Epilepsy & behavior : E&B.. 2002 Dec;3(6S1):2-6. PMID: 12609305 [PubMed – as supplied by publisher]. HTML PDF

Cole AJ, Dichter M. Neuroprotection and antiepileptogenesis: Overview, definitions, and context. Neurology. 2002 Nov 12;59(9 Suppl 5):S1-S2. No abstract available. PMID: 12428024 [PubMed – as supplied by publisher] PDF

Dichter MA, Cole AJ. Neuroprotection and antiepileptogenesis: Where are we now? Neurology. 2002 Nov 12;59(9 Suppl 5):S36-S38. No abstract available. PMID: 12428031 [PubMed – as supplied by publisher]. PDF

Cole AJ, Koh S, Zheng Y. Are seizures harmful: what can we learn from animal models? Prog Brain Res. 2002;135:13-23. Review. PMID: 12143335 [PubMed – indexed for MEDLINE]. PDF

Brisman JL, Cosgrove GR, Cole AJ. Phosphorylation of P42/P44 MAP kinase and DNA fragmentation in the rat perforant pathway stimulation model of limbic epilepsy. Brain Res. 2002 Apr 12;933(1):50-9. PDF

Doherty CP, Hoch D, Cole AJ.  Surgery for temporal-lobe epilepsy. N Engl J Med. 2002 Jan 24;346(4):292-5.

Sheen VL, Dixon PH, Fox JW, Hong SE, Kinton L, Sisodiya SM, Duncan JS, Dubeau F, Scheffer IE, Schachter SC, Wilner A, Henchy R, Crino P, Kamuro K, DiMario F, Berg M, Kuzniecky R, Cole AJ, Bromfield E, Biber M, Schomer D, Wheless J, Silver K, Mochida GH, Berkovic SF, Andermann F, Andermann E, Dobyns WB, Wood NW, Walsh CA. Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. Hum Mol Genet. 2001 Aug 15;10(17):1775-83. PDF

Doherty CP, Cole AJ. The requirement for ictal EEG recordings prior to temporal lobe epilepsy surgery. Arch Neurol. 2001 Apr;58(4):678-80. PDF

Cole AJ. Is epilepsy a progressive disease? The neurobiological consequences of epilepsy. Epilepsia. 2000;41 Suppl 2:S13-22. PDF

Tanabe SM, Grant PE, Cosgrove GR, Hoch DB and Cole AJ. Delayed diagnosis of lesional epilepsy: Utility of modern imaging. Neurology and Clinical Neurophysiology, 2000 Article 1A:1-8. PDF

Koh S, Storey TW, Santos TC, Mian AY, Cole AJ. Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood. Neurology. 1999 Sep 22;53(5):915-21. PDF

Wiederin TBJ, Chiappa KH, Krings T, Cuffin BN, Hoch DB, Cole AJ and Cosgrove GR. The utilitity of dipole source analysis of seizure onsets in the localization of epileptogenic zones as assessed by postsurgical outcome. Contemporary Neurology, 1999 Article 1A:2-10.

Mendola JD, Rizzo JF 3rd, Cosgrove GR, Cole AJ, Black P, Corkin S. Visual discrimination after anterior temporal lobectomy in humans. Neurology. 1999 Mar 23;52(5):1028-37. PDF

Hu RQ, Koh S, Torgerson T, Cole AJ. Neuronal stress and injury in C57/BL mice after systemic kainic acid administration. Brain Res. 1998 Nov 9;810(1-2):229-40. PDF

Murray B, Alessandrini A, Cole AJ, Yee AG, Furshpan EJ. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11975-80. PDF

Tatum WO 4th, Ross J, Cole AJ. Epileptic pseudodementia. Neurology. 1998 May;50(5):1472-5. PDF

Weiss S, Cataltepe O, Cole AJ. Anatomical studies of DNA fragmentation in rat brain after systemic kainate
administration. Neuroscience. 1996 Sep;74(2):541-51. PDF

Benson RR, Logan WJ, Cosgrove GR, Cole AJ, Jiang H, LeSueur LL, Buchbinder BR, Rosen BR, Caviness VS Jr. Functional MRI localization of language in a 9-year-old child. Can J Neurol Sci. 1996 Aug;23(3):213-9.

Bhat RV, Cole AJ, Baraban JM. Chronic cocaine treatment suppresses basal expression of zif268 in rat
forebrain: in situ hybridization studies. J Pharmacol Exp Ther. 1992 Oct;263(1):343-9. PDF

Bhat RV, Cole AJ, Baraban JM. Role of monoamine systems in activation of zif268 by cocaine. J Psychiatry Neurosci. 1992 Sep;17(3):94-102. Review. PDF

Cole AJ, Bhat RV, Patt C, Worley PF, Baraban JM. D1 dopamine receptor activation of multiple transcription factor genes in rat striatum. J Neurochem. 1992 Apr;58(4):1420-6. PDF

Bhat RV, Worley PF, Cole AJ, Baraban JM. Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268. Brain Res Mol Brain Res. 1992 Apr;13(3):263-6. PDF

Worley PF, Christy BA, Nakabeppu Y, Bhat RV, Cole AJ, Baraban JM. Constitutive expression of zif268 in neocortex is regulated by synaptic activity. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5106-10. PDF

Cole AJ, Abu-Shakra S, Saffen DW, Baraban JM, Worley PF. Rapid rise in transcription factor mRNAs in rat brain after electroshock-induced seizures. J Neurochem. 1990 Dec;55(6):1920-7. PDF

Cole AJ, Saffen DW, Baraban JM, Worley PF. Synaptic regulation of transcription factor mRNA in the rat hippocampus. Adv Neurol. 1990;51:103-8.

Worley PF, Cole AJ, Murphy TH, Christy BA, Nakabeppu Y, Baraban JM. Synaptic regulation of immediate-early genes in brain. Cold Spring Harb Symp Quant Biol. 1990;55:213-23.

Worley PF, Cole AJ, Saffen DW, Baraban JM. Regulation of immediate early genes in brain: role of NMDA receptor activation. Prog Brain Res. 1990;86:277-85.

Cole AJ, Aubé M. Migraine with vasospasm and delayed intracerebral hemorrhage. Arch Neurol. 1990 Jan;47(1):53-6.PMID: 2294895. PDF

Stratton KR, Cole AJ, Pritchett J, Eccles CU, Worley PF, Baraban JM. Intrahippocampal injection of pertussis toxin blocks adenosine suppression of synaptic responses. Brain Res. 1989 Aug 14;494(2):359-64. PDF

Cole AJ, Saffen DW, Baraban JM, Worley PF. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation. Nature. 1989 Aug 10;340(6233):474-6. PDF

Saffen DW, Cole AJ, Worley PF, Christy BA, Ryder K, Baraban JM. Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7795-9. PDF

Cole AJ, Kuzniecky R, Karpati G, Carpenter S, Andermann E, Andermann F. Familial myopathy with changes resembling inclusion body myositis and periventricular leucoencephalopathy. A new syndrome. Brain. 1988 Oct;111 ( Pt 5):1025-37. PDF

Cole AJ, Andermann F, Taylor L, Olivier A, Rasmussen T, Robitaille Y, Spire JP. The Landau-Kleffner syndrome of acquired epileptic aphasia: unusual clinical outcome, surgical experience, and absence of encephalitis. Neurology. 1988 Jan;38(1):31-8. PDF

Cole AJ, Gloor P, Kaplan R. Transient global amnesia: the electroencephalogram at onset. Ann Neurol. 1987 Dec;22(6):771-2. PDF

Dr. Daniel Hoch

Prady SL, Norris D, Lester JE, Hoch DB. Expanding the guidelines for electronic communication with patients: application to a specific tool. J Am Med Inform Assoc. 2001 Jul-Aug;8(4):344-8.

Dworetzky BA, Hoch DB, Wagner AK, Salmanson E, Shanahan CW, Bromfield EB. The impact of a single seizure on health status and health care utilization. Epilepsia. 2000 Feb;41(2):170-6.

Hoch DB, Norris D, Lester JE, Marcus AD. Information exchange in an epilepsy forum on the World Wide Web. Seizure. 1999 Feb;8(1):30-4.

Pohlmann-Eden B, Hoch DB, Cochius JI, Chiappa KH. Periodic lateralized epileptiform discharges-a critical review. J Clin Neurophysiol. 1996 Nov;13(6):519-30.

Hoch DB, Hill RA, Oas KH. Epilepsy and mental decline. Neurol Clin. 1994 Feb;12(1):101-13. Review.

Hoch DB. Brain death: a diagnostic dilemma. J Nucl Med. 1992 Dec;33(12):2211-3.

Nuwer MR, Banoczi WR, Cloughesy TF, Hoch DB, Peacock W, Levesque MF, Black KL, Martin NA, Becker DP. Topographic mapping of somatosensory evoked potentials helps identify motor cortex more quickly in the operating room. Brain Topogr. 1992 Fall;5(1):53-8.

Geraghty JJ, Hoch DB, Robert ME, Vinters HV. Fatal puerperal cerebral vasospasm and stroke in a young woman. Neurology. 1991 Jul;41(7):1145-7.

Berry BW, Boland LM, Hoch DB, Dingledine R. L-glutamate binding site on N18-RE-105 neuroblastoma hybrid cells is not coupled to an ion channel. J Neurochem. 1988 Oct;51(4):1176-83.

Hoch DB, Dingledine R. GABAergic neurons in rat hippocampal culture. Brain Res. 1986 Feb;390(1):53-64.

Hoch DB, Dingledine RJ, Wilson JE.  Long-term potentiation in the hippocampal slice: possible involvement of pyruvate dehydrogenase. Brain Res. 1984 Jun 4;302(1):125-34.

Hoch DB, Wilson JE, Dingledine RJ. Factors affecting the phosphorylation of a 41,000 dalton protein of hippocampal subcellular fractions. Brain Res. 1984 Jun 4;302(1):117-24.

Hoch DB, Wilson JE. Effects of calcium, strontium, and barium ions on phosphorylation of hippocampal proteins in vitro. J Neurochem. 1984 Jan;42(1):54-8.

Myers RD, Hoch DB. Localization of sites in the brain mediating alcohol drinking induced by tetrahydropapaveroline (THP). Curr Alcohol. 1979;5:29-44.

Myers RD, Hoch DB. 14C-dopamine microinjected into the brain-stem of the rat: dispersion kinetics, site content and functional dose. Brain Res Bull. 1978 Nov-Dec;3(6):601-9.

Dr. Elizabeth Thiele

Valencia I, Pfeifer H, Thiele EA. General anesthesia and the ketogenic diet: clinical experience in nine patients. Epilepsia. 2002 May;43(5):525-9.

Thiele EA, Gonzalez-Heydrich J, Riviello JJ Jr. Epilepsy in children and adolescents. Child Adolesc Psychiatr Clin N Am. 1999 Oct;8(4):671-94. Review.

So GM, Thiele EA, Sanger T, Schmid R, Riviello JJ Jr. Electroencephalogram and clinical focalities in juvenile myoclonic epilepsy. J Child Neurol. 1998 Nov;13(11):541-5.

Pohl-Koppe A, Burchett SK, Thiele EA, Hafler DA.  Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. J Neuroimmunol. 1998 Nov 2;91(1-2):19-27.

Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME.  Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol. 1998 Apr;18(4):1946-55.

Forman SA, Yellen G, Thiele EA. Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation. Nat Genet. 1996 Aug;13(4):396-7.

Thiele EA, Riviello JJ. Scopolamine patch-induced unilateral mydriasis. Pediatrics. 1995 Sep;96(3 Pt 1):525.

Thiele EA, Eipper BA. Effect of secretagogues on components of the secretory system in AtT-20 cells. Endocrinology. 1990 Feb;126(2):809-17.

Thiele EA, Marek KL, Eipper BA. Tissue-specific regulation of peptidyl-glycine alpha-amidating monooxygenase expression. Endocrinology. 1989 Nov;125(5):2279-88.

Eipper BA, Park LP, Dickerson IM, Keutmann HT, Thiele EA, Rodriguez H, Schofield PR, Mains RE. Structure of the precursor to an enzyme mediating COOH-terminal amidation in peptide biosynthesis. Mol Endocrinol. 1987 Nov;1(11):777-90.

Strittmatter SM, Thiele EA, De Souza EB, Snyder SH. Angiotensin-converting enzyme in the testis and epididymis: differential development and pituitary regulation of isozymes. Endocrinology. 1985 Oct;117(4):1374-9.

Strittmatter SM, Thiele EA, Kapiloff MS, Snyder SH. A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. J Biol Chem. 1985 Aug 15;260(17):9825-32.

Thiele EA, Strittmatter SM, Snyder SH. Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain. Biochem Biophys Res Commun. 1985 Apr 16;128(1):317-24.

Dr. Sydney Cash

Bianchi, M. T., B. M. Alexander and SS. Cash (2008). “Incorporating Uncertainty Into Medical Decision Making: An Approach to Unexpected Test Results.” Med Decis Making. 29(1): 116-124.

Bianchi, M. T., J. Pathmanathan and SS. Cash (2008). “From ion channels to complex networks: Magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy.” Med Hypotheses.72(3): 297-305.

Costello, D. J., D. C. Shields, SS. Cash, E. N. Eskandar, G. R. Cosgrove and A. J. Cole (2008). “Consideration of epilepsy surgery in adults should be independent of age.” Clin Neurol Neurosurg. 111(3): 240-245.

Keller, C. J., SS. Cash, S. Narayanan, C. Wang, R. Kuzniecky, C. Carlson, O. Devinsky, T. Thesen, W. Doyle, A. Sassaroli, D. A. Boas, I. Ulbert and E. Halgren (2009). “Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex.” Journal of Neuroscience Methods.179(2): 208-218.

Mueen, A., Keogh, E., Zhu, Q., Cash, SS., Westover, B. “Exact Discovery of Time Series Motifs.” (2009) Proceedings of the SIAM International Conference on Data Mining (SDM 2009).

Gow, D., Keller C., Meng, N., Eskandar, E. and Cash, SS. (2009) “Parallel versus serial processing dependencies in the perisylvian speech network: A Granger analysis of intracranial EEG data” Brain and Language, 110(1):43-48.

Cash, SS., E. Halgren, N. Dehghani, A. O. Rossetti, E. B. Bromfield, T. Thesen, C. Wang, O. Devinsky, R. Kuzniecky, W. Doyle, J. R. Madsen, L. Eross, P. Halasz, G. Karmos and I. Ulbert (2009). “The Human K-Complex Represents an Isolated Cortical Down State.” Science 5930(324): 1084-1087.

Kramer, MA., Eden, UT., Cash, SS., Kolaczyk, ED., (2009) “Network inference – with confidence – from multivariate time series,” Phys Review E. 79(6): online.

Sahin, NT., Pinker, S., Cash, SS., Schomer, D., Halgren, E., (2009) “Sequential Processing of Lexical, Grammatical and Phonological Information within Broca’s Area,” Science in press.

Last Updated: December 2016